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Results for "

Smoothened receptor

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18287A
    MRT-83 hydrochloride

    		Smo Cancer
    MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .
    MRT-83 hydrochloride
  • HY-13242
    Taladegib
    1 Publications Verification

    LY2940680

    		 Smo Cancer
    Taladegib (LY2940680) is an antagonist of the smoothened receptor.
    Taladegib
  • HY-15108
    Purmorphamine
    10+ Cited Publications

    		 Organoid Smo Autophagy Neurological Disease Cancer
    Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
    Purmorphamine
  • HY-12848S
    SAG-d3

    		Smo Cancer
    SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].
    SAG-d3
  • HY-12848
    SAG
    Maximum Cited Publications
    18 Publications Verification

    		 Smo Cancer
    SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
    SAG
  • HY-12848B
    SAG hydrochloride
    Maximum Cited Publications
    18 Publications Verification

    		 Smo Cancer
    SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
    SAG hydrochloride
  • HY-12848C
    SAG dihydrochloride
    Maximum Cited Publications
    18 Publications Verification

    		 Smo Cancer
    SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
    SAG dihydrochloride
  • HY-15108G
    Purmorphamine

    		Smo Neurological Disease Cancer
    Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM .
    Purmorphamine
  • HY-108507
    MRT-10

    		Smo Cancer
    MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .
    MRT-10
  • HY-145387
    MRT-81

    		Smo Cancer
    MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer .
    MRT-81
  • HY-12848A
    (Rac)-SAG

    		Smo Cancer
    (Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .
    (Rac)-SAG
  • HY-12317
    GSA-10

    		Smo Hedgehog Cancer
    GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .
    GSA-10

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